Two sample MR report
HLA-C_Dendritic Cell (DC) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 19 | 0.0365857 | 0.0432188 | 0.4090201 |
| Weighted median | 19 | -0.0143243 | 0.0079303 | 0.0708729 |
| Inverse variance weighted | 19 | -0.0154158 | 0.0057923 | 0.0077810 |
| Simple mode | 19 | -0.0096250 | 0.0167641 | 0.5729753 |
| Weighted mode | 19 | -0.0089795 | 0.0185016 | 0.6332912 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 18.2563 | 17 | 0.3728472 |
| Inverse variance weighted | 19.8387 | 18 | 0.3419734 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0314764 | 0.0259303 | 0.2413872 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003209 | 0 | TRUE | 0.0895838 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
